C Bing

D Stejskal

Diego Fernández-García

DM Selva

E Garcia-Fuentes

E Hu

Eduardo García-Fuentes

FJ Tinahones

Francisco J. Tinahones

FY Gong

G Haemmerle

G Sesti

GH Ballantyne

I Dahlman

Joan Vendrell

Juan Alcaide

K Hirai

Lourdes Garrido-Sánchez

M Guerre-Millo

MF White

MP Marrades

N Barbarroja

P Libby

P Trayhurn

Pablo Perez-Martinez

PT Todorov

ST Russell

Stephen L. Atkin

T Gohda

T Mracek

T Tada

T Tzanavari

U Smith

V Ceperuelo-Mallafré

V Large

V Rolli

Xavier Escoté

Y Bao

PLoS ONE

English

PubMed

 glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR)., lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed.. may be a useful target in obesity and related disorders, such as diabetes

Garrido-Sánchez Lourdes

García-Fuentes Eduardo

Fernández-García Diego

Escoté Xavier

Alcaide Juan

Perez-Martinez Pablo

Vendrell Joan

Tinahones Francisco J.

Public Library of Science (PLOS)

Zinc-Alpha 2-Glycoprotein Gene Expression in Adipose Tissue Is Related with Insulin Resistance and Lipolytic Genes in Morbidly Obese Patients

OBJECTIVE: Zinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR). METHODS: mRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed. RESULTS: The morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL. CONCLUSIONS: ZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes

Francisco J Tinahones

Directory of Open Access Journals

Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients.

Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;OBJECTIVE
Zinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR).
METHODS
mRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed.
RESULTS
The morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL.
CONCLUSIONS
ZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes.Ye

Garrido-Sánchez, Lourdes

García-Fuentes, Eduardo

Fernández-García, Diego

Escoté, Xavier

Alcaide, Juan

Pérez-Martínez, Pablo

Vendrell, Joan

Tinahones, Francisco J

RISalud-ANDALUCÍA

Garrido-Sánchez L., García-Fuentes E., Fernández-García D., Escoté X., Alcaide J., Perez-Martinez P., Vendrell J., Tinahones FJ.

Repositori Institucional URV

Crossref

OBJECTIVE: Zinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR). METHODS: mRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed. RESULTS: The morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL. CONCLUSIONS: ZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes.This work was supported in part by grants from the Programa Juan de la Cierva (JCI-2009-04086), Instituto de Salud Carlos III (CP04/00133, PS09/01060, PS09/00997), Servicio Andaluz de Salud (PI0255/2007)

REPISALUD (Instituto de Salud Carlos III)

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Zinc-Alpha 2-Glycoprotein Gene Expression in Adipose Tissue Is Related with Insulin Resistance and Lipolytic Genes in Morbidly Obese Patients

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Directory of Open Access Journals

Public Library of Science (PLOS)

RISalud-ANDALUCÍA

Repositori Institucional URV

Crossref

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