A Brescia

A Dominijanni

AC van Lindert

F Cariati

F Zullo

KN Gaarenstroom

M Morelli

NF Hacker

P Puzzonia

S Del Negro

S Durdević

English

PubMed

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MEETING ABSTRACT Open Access
Use of platelet gel after surgery for wound
breakdown prevention in recurrent vulvar cancer:
case report
M Morelli1*, A Dominijanni2, S Del Negro1, A Brescia2, F Cariati1, P Puzzonia2, F Zullo1
From de Senectute: Age and Health Forum
Catanzaro, Italy. 5-7 December 2009
Background
Vulvar carcinomas comprise almost 5% of all malignant
tumors of the female genital tract [1]. Primary therapeu-
tic approach is considered a radical surgery [2].
Infection and wound breakdown are the most common
complications, these occur in approximately 40-60% of
patients [3]. Objective to value the efficacy of platelet
gel as support for reconstructive surgery in recurrent
vulvar cancer.
Materials and methods
Five old caucasian women with a history of vulvar cancer,
referred to our Department, were treated for recurrent
vulvar cancer. Before the vulvar surgery recostruction, an
application of platelet gel was performed.
Results
Our data about wound healing, compared to results of
previous cases of vulvar recurrence treated by our
department, immediately show a reduction of complica-
tions, early healing and patient mobilization with less
hospital stay, minimizing the costs. Other advantages of
this new technique are the facility of application, no
influence on operative time and low cost.
Conclusions
In consideration of the most frequent complications that
are reported after surgical treatment of vulvar recur-
rence, as difficult and longer healing due to frequent
necrosis and breakdown of wounds, we had experimen-
ted with the use of platelet gel [3]. In fact, thanks to its
properties of regenerating and repairing tissues, platelet
gel is being used ever more frequently in reconstructive
surgery [4]. The biological properties of platelet gel
are basically due to the high concentrations of growth
factors (GF) [4].
Author details
1Department of Obstetrics and Gynecology, University ‘Magna Graecia’,
Catanzaro, Italy. 2Servizio di Immunoematologia e Medicina Trasfusionale,
Hospital ‘Pugliese-Ciaccio’, Catanzaro, Italy.
Published: 19 May 2010
References
1. Durdević S, Hadzić B, Petrović D: Radical vulvectomy with inguino-femoral
lymphadenectomy in the surgical treatment of vulvar carcinoma. Med
Pregl 2000, 53:607-12.
2. Hacker NF: Current management of early vulvar cancer. Ann Acad Med
Singapore 1998, 27:688-92.
3. Gaarenstroom KN, Kenter GG, Trimbos JB, Agous I, Amant F, Peters AA,
Vergote I: Postoperative complication after vulvectomy and
inguinofemoral lymphadenectomy using separate groin incisions. Int J
Gynecol cancer 2003, 13:522-7.
4. van Lindert AC, Symons EA, Damen BF, Heintz AP: Wound healing after
radical vulvectomy and inguino-femoral lymphadenectomy experience
with granulocyte colony stimulating factor (filgrastim, r-metHuG-CSF).
Eur J Obstet Gynecol Reprod Biol 1995, 62:217-9.
doi:10.1186/1471-2318-10-S1-A67
Cite this article as: Morelli et al.: Use of platelet gel after surgery for
wound breakdown prevention in recurrent vulvar cancer: case report.
BMC Geriatrics 2010 10(Suppl 1):A67.
1Department of Obstetrics and Gynecology, University ‘Magna Graecia’,
Catanzaro, Italy
Morelli et al. BMC Geriatrics 2010, 10(Suppl 1):A67
http://www.biomedcentral.com/1471-2318/10/S1/A67
© 2010 Morelli et al; licensee BioMed Central Ltd.


Use of platelet gel after surgery for wound breakdown prevention in recurrent vulvar cancer: case report

Puzzonia P

Cariati F

Brescia A

Del Negro S

Dominijanni A

Morelli M

Zullo F

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BMC Geriatrics

Crossref

AP: Wound healing after radical vulvectomy and inguino-femoral lymphadenectomy experience with granulocyte colony stimulating factor (filgrastim, r-metHuG-CSF).

Current management of early vulvar cancer. Ann Acad Med Singapore

Petrović D: Radical vulvectomy with inguino-femoral lymphadenectomy in the surgical treatment of vulvar carcinoma. Med Pregl

Vergote I: Postoperative complication after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions.

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Use of platelet gel after surgery for wound breakdown prevention in recurrent vulvar cancer: case report

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