Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3−NKp46+CD56+ cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-γ. NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils. During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models. Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality. Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions. Herein, we review the potential role of NK cells during severe sepsis and septic shock

Bléry, Mathieu

Chiche, Laurent

Farnarier, Catherine

Forel, Jean-Marie

Papazian, Laurent

Thomas, Guillemette

Vely, Fréderic

Vivier, Eric

English

PubMed

Laurent Chiche

Jean-Marie Forel

Guillemette Thomas

Catherine Farnarier

Fréderic Vely

Mathieu Bléry

Laurent Papazian

Eric Vivier

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Journal of Biomedicine and Biotechnology

The Role of Natural Killer Cells in Sepsis

Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3−NKp46+CD56+cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-γ. NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils. During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models. Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality. Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions. Herein, we review the potential role of NK cells during severe sepsis and septic shock.</jats:p

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International audienceSevere sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3(-)NKp46(+)CD56(+) cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-γ. NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils. During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models. Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality. Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions. Herein, we review the potential role of NK cells during severe sepsis and septic shock

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The role of natural killer cells in sepsis

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A .R .K e r r ,L .A .S .K i r k h a m ,A .K a d i o g l ue ta l . ,“ I d e n t i ﬁ c a t i o n ofadetrimental roleforNK cellsinpneumococcalpneumonia and sepsis in immunocompromised hosts,”

a l z e r ,M .B l´

a l z e r ,M .D a l o d ,S .H .R o b b i n s ,L .Z i t v o g e l ,a n dE .V i v i e r , “Natural-killercells anddendritic cells:“L’union faitlaforce”,”

A modular analysis frameworkforbloodgenomicsstudies:applicationtosystemic lupus erythematosus,”

a n d e l b o i m ,N .L i e b e r m a n ,M .L e ve ta l . ,“ R e c o g n i t i o n of haemagglutinins on virus-infected cells by NKp46 activates lysisby humanNK cells,”

A n g u s ,W .T .L i n d e - Z w i r b l e ,J .L i d i c k e r ,G .C l e r m o n t

a z o d i e r ,V .M a r i n ,D .N o v i c ke ta l . ,“ S e v e r ei m b a l a n c e of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome,”

Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction,” Clinical Immunology,v o l .

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder,”

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis,”

Antibiotic usage and resistance: gaining or losing ground on infections in critically ill patients?”

Arrested natural killer cell development associated with transgene insertion into the

B ry c e s o n ,C .F a u r i a t ,J .M .N u n e se ta l . ,“ F u n c t i o n a la n a l -ysis of human NK cells by ﬂow cytometry,”

Bj¨ orkstr¨ o m ,T .L i n d g r e n ,M .S t o l t ze ta l . ,“ R a p i d expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus,”

C a r s o n ,H .Y u ,J .D i e r k s h e i d ee ta l . ,“ Af a t a lc y t o k i n e -induced systemic inﬂammatory response reveals a critical role forNK cells,”

C.A.Biron,K.S.Byron,andJ.L.Sullivan,“Severe herpesvirus infections in an adolescent without natural killer cells,” New England

C.Bone,“Immunologicdissonance:a continuingevolution in our understanding of the systemic inﬂammatory response syndrome (SIRS) and the Multiple Organ Dysfunction Syndrome

CD56CD16 killer Ig-like receptor NK cells display longer telomeres and acquire features of CD56 NK cells upon activation,”

Cellular immunity and active human cytomegalovirus infection in patients with septic shock,”

Compartmentalization of the inﬂammatory response in sepsis and

Conﬁrmatory interleukin-1 receptor antagonisttrial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial,” Critical Care Medicine,v o l .2 5 ,n o .7 ,p p .

D e lling e r ,M.M.L ev y ,J .M.C ar le te tal. ,“ S u rvi vingse p sis campaign: international guidelines for management of severe sepsis and septic shock:

D¨ o c k e ,F .R a n d o w ,U .S y r b ee ta l . ,“ M o n o c y t ed e a c t i v a -tioninsepticpatients:restorationbyIFN-γ treatment,”Nature Medicine,

Deﬁnitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.

Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production,”

Direct recognition of cytomegalovirus by activating and inhibitory

Distinct organ-dependent mechanismsforthecontrol ofmurinecytomegalovirus infection by natural killer cells,”

Dondero et al.,“The interaction of humannatural killercells witheither unpolarized orpolarized macrophages results in diﬀerent functional outcomes,”

Early alterations of theinnateandadaptive immunestatusesinsepsisaccordingto the type of underlying infection,”

Early assessment of leukocyte alterations at diagnosis of septic shock,”

Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis,”

Early goal-directed therapy in the treatment of severe sepsis and septic shock,”

F i s h e rJ r . ,J .M .A g o s t i ,S .M .O p a le ta l . ,“ T r e a t m e n to f septic shockwiththe tumornecrosisfactor receptor: Fc fusion protein,”

Fluid resuscitation inﬂuences cardiovascular performance and mortality in a murine model of sepsis,”

from CD3(-)NKp46(+) to post-genomics meta-analyses,”

h i c h e ,J .M .F o r e l ,A .R o c he ta l . ,“ A c t i v ec y t o m e g a l o v i r u s infection is common in mechanically ventilated medical intensive care unit patients,”

H.Heremans,C.Dillen,J.VanDamme,andA.Billiau,“Essential role fornatural killer cells in the lethal lipopolysaccharideinduced Shwartzman-like reaction in mice,”

Human natural killer cell deﬁciencies and susceptibility to infection,”

Human primary immunodeﬁciency diseases,”

IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis,”

IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching,”

In vitro studies of natural killer cell activity in septic shock patients. Response to a challenge with α-interferon and

In vivo natural killer cell activities revealed by natural killer cell-deﬁcient mice,”

Innate immunity to malaria,”

Innate or adaptive immunity? The example of natural killer cells,” Science,v o l .

K u i j p e r s ,P .A .B a a r s ,C .D a n t i n ,M .V a nD e nB u r g

Le Deist et al.,“Perforin genedefects infamilialhemophagocyticlymphohistiocytosis,”

Lymphocyte subset numbers depend on the bacterial origin of sepsis,”

M´ e r e s s e ,E .V i v i e r ,a n dJ .T r o w s d a l e , “Interactions between human NK cells and macrophages in response to Salmonella infection,”

M.C.Jacksonet al.,“Presymptomatic prediction of sepsis in intensive care unit patients,”

n s i n g e r ,J .S .M c D o n o u g h ,L .D .S h u l t z ,T .A .F e r g u s o n

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors.

Natural killer cell-directed therapies: moving from unexpected results to successful strategies,”

Natural killer cells participate in bacterial clearance during septic peritonitis through interactions with macrophages,”

Naturalkillercells contributetothelethality of a murine model of Escherichi coli infection,” Surgery,v o l .

NK but not CD1-restricted NKT cells facilitate systemicinﬂammationduring polymicrobialintra-abdominal sepsis,”

NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection,”

Pathogenesis of hemophagocytic syndrome

Reciprocal regulation of human natural killer cells and macrophages associatedwithdistinctimmunesynapses,”Blood,vol.109,no. 9,

S c o t t ,J .J .H o t h ,S .A .G a r d n e r ,J .C .P e y t o n ,a n dW .G . Cheadle, “Naturalkiller cell activationprimes macrophagesto clear bacterial infection,” American Surgeon,v o l .6 9 ,n o .8 ,p p .

S h e r w o o d ,V .T .E n o h ,E .D .M u r p h e y ,a n dC .Y .L i n , “Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture,”

Sepsisinduced apoptosis causes progressive profound depletion

Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells,”

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development,”

The defensive alliance between neutrophils and NK cells as a novel arm of innate immunity,”JournalofLeukocyteBiology,vol.89,no.2,pp.221– 233,

Unravelling natural killer cell function: triggering and inhibitory human

Virological and immunological features of active cytomegalovirus infection in nonimmunosuppressed patients in a surgical and trauma intensive care unit,”

W e i s s l e r ,L .P .N i c o d ,M .F .L i p s c o m b ,a n dG .B .T o e w s , “Natural killer cell function in humanlung is compartmentalized,”

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The Role of Natural Killer Cells in Sepsis

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