Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

A Bateman; A. M Reitzel; Bernard M. Degnan; C Larroux; C. M Zmasek; C. Y Chang; Claire Larroux; D. M Hillis; D. S Geller; E Aggelidou; E. A Ortlund; Eric A. Ortlund; F Armougom; F Jacob; G Benoit; G Sun; G. B Wisely; G. J Kleywegt; Geeta N. Eick; H Escriva; H Escriva; H Greschik; H Gronemeyer; I. N Krylova; J Schultz; J. A Nylander; J. M Maglich; J. P Huelsenbeck; J. P Renaud; J. T Bridgham; J. W Thornton; Jamie T. Bridgham; Joseph W. Thornton; K Suino; K. D Baker; K. I Pardee; Kirti Deshpande; L Shan; Laurence D. Hurst; M Anisimova; M Srivastava; M Srivastava; M Wiens; M. J West-Eberhardt; M. W Kirschner; Marie E. A. Gauthier; Michael J. Harms; N Eswar; N King; N Shubin; N. H Putnam; P. D Thomas; R. C Edgar; R. G Beiko; R. X Xu; S Bertrand; S Chen; S Guindon; W Feng; X Yuan; Y Kim; Z Wang

Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

Abstract

Phylogenetic reconstruction of the structure and function of the ancestor of the nuclear receptor protein family reveals how functional diversity evolves by subtle tinkering with an ancestral template

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