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A Dabestani

AE Yanni

Ameeth Vedre

APN Fontes-Sousa

Augusta Pelosi

C Vuille

C-M Yu

CJ Lavie

FA Masoudi

FL Ruberg

George S Abela

GISSI-HF investigators

GS Abela

H Ashrafian

H Dokainish

HC Chiu

IG Poornima

J Kjekshus

J Simes

J-H Wu

Jack Rubinstein

JE Sanderson

JH O'Keefe

JM McGavock

K Kalantar-Zadeh

KY Stokes

M de Lorgeril

M Jessup

M Van Heek

M Wang

MG Dickinson

Pavan Kotaru

S Sharma

SA Hunt

SF Nagueh

V Zaca

W Rosamond

Y Huang

English

PubMed

Springer - Publisher Connector

Hypercholesterolemia and Myocardial function evaluated via Tissue Doppler Imaging

Abstract Objective To establish a link between hypercholesterolemia and myocardial dysfunction. Background Heart failure is a complex disease involving changes in systolic and diastolic function. Newer echocardiographic imaging modalities may be able to detect discreet changes in myocardial function associated with hypercholesterolemia. Therefore we sought to establish a link between hypercholesterolemia and myocardial dysfunction with tissue Doppler imaging (TDI). Methods Twenty-seven rabbits were studied: 7 were fed normal chow (group 1) and 20 a high cholesterol diet (10 with ezetimibe, 1 mg/kg/day; group 2 and 10 without, group 3). Echocardiographic images were obtained under general anesthesia. Serum cholesterol levels were obtained at baseline, 3 and 6 months and myocardial cholesterol levels measured following euthanasia. Results Doppler measurements, including E/A, E'/A' and S' were significantly lower in group 3 compared to both groups 1 and 2 but no significant differences were noted in chamber sizes or ejection fraction among the groups. Average serum cholesterol was higher in group 3 compared to groups 1 and 2 respectively (495 ± 305 mg/dl vs. 114 ± 95 mg/dl and 87 ± 37 mg/dl; p 2 = 0.17 p = 0.04, r2 = 0.37 p = 0.001 and r2 = 0.24 p = 0.01). Conclusion Cholesterol load in the serum and myocardium was significantly associated with decreased systolic and diastolic function by TDI. Moreover, lipid lowering was protective.</p

Kotaru Pavan

Vedre Ameeth

Pelosi Augusta

Rubinstein Jack

Abela George S

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Hypercholesterolemia and Myocardial function evaluated via Tissue Doppler Imaging

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