The selection of agents for any treatment regimen is in part influenced by physician and patient attitudes. This study investigated attitudinal motivators and barriers to the use of self-injectable antiretroviral agents among physicians and patients and measured the degree of concordance between physician and patient perspectives

Clotet, Bonaventura

Cohen, Calvin

Cooper, Vanessa

Fisher, Martin

Fumaz, Carmina R

Horne, Robert

Katlama, Christine

Kovacs, Colin

Kulasegaram, Ranjababu

Shalit, Peter

Slim, Jihad

Tsoukas, Christos

Youle, Michael

English

PubMed

Abstract Background The selection of agents for any treatment regimen is in part influenced by physician and patient attitudes. This study investigated attitudinal motivators and barriers to the use of self-injectable antiretroviral agents among physicians and patients and measured the degree of concordance between physician and patient perspectives. Methods Attitudes toward prescribing and usage of self-injectable antiretroviral therapy (SIAT) were assessed by structured interview in 2 cohorts sampled from the European Union and the USA: 499 HIV-treating physicians and 603 treatment-experienced HIV-infected patients. Motivators and barriers to prescribing SIAT were identified from statistical analysis of the associations between physicians' ratings of enfuvirtide-based therapy compared to standard oral-based therapy and 2 indicators of enfuvirtide prescribing behavior. Patients' attitudes were assessed by their responses to a written profile of enfuvirtide and their ratings of the likelihood of accepting a treatment offer. Results Both indicators of SIAT prescribing behavior were predicted by the same pattern of physician beliefs. Nonprescribing was associated with: (1) the belief that offering enfuvirtide would be perceived negatively by patients, leading to treatment refusal and nonadherence; (2) the belief that prescribing enfuvirtide is harder to justify in terms of time/resources; and (3) a lack of confidence in the efficacy and use of enfuvirtide in practice (all p  Conclusion Physician and patient beliefs about SIAT influence prescribing behavior and compliance yet may not be concordant, with patients having more positive attitudes towards SIAT than anticipated by physicians.</p

Cohen Calvin

Fisher Martin

Youle Michael

Kulasegaram Ranjababu

Fumaz Carmina R

Clotet Bonaventura

Katlama Christine

Kovacs Colin

Horne Robert

Slim Jihad

Shalit Peter

Cooper Vanessa

Tsoukas Christos

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AIDS Research and Therapy

Prescribing and using self-injectable antiretrovirals: How concordant are physician and patient perspectives?

Springer - Publisher Connector

Abstract
              
                Background
                The selection of agents for any treatment regimen is in part influenced by physician and patient attitudes. This study investigated attitudinal motivators and barriers to the use of self-injectable antiretroviral agents among physicians and patients and measured the degree of concordance between physician and patient perspectives.
              
              
                Methods
                Attitudes toward prescribing and usage of self-injectable antiretroviral therapy (SIAT) were assessed by structured interview in 2 cohorts sampled from the European Union and the USA: 499 HIV-treating physicians and 603 treatment-experienced HIV-infected patients. Motivators and barriers to prescribing SIAT were identified from statistical analysis of the associations between physicians' ratings of enfuvirtide-based therapy compared to standard oral-based therapy and 2 indicators of enfuvirtide prescribing behavior. Patients' attitudes were assessed by their responses to a written profile of enfuvirtide and their ratings of the likelihood of accepting a treatment offer.
              
              
                Results
                Both indicators of SIAT prescribing behavior were predicted by the same pattern of physician beliefs. Nonprescribing was associated with: (1) the belief that offering enfuvirtide would be perceived negatively by patients, leading to treatment refusal and nonadherence; (2) the belief that prescribing enfuvirtide is harder to justify in terms of time/resources; and (3) a lack of confidence in the efficacy and use of enfuvirtide in practice (all p < 0.05). However, physicians' beliefs were not in concordance with patients' views. After reading a profile of enfuvirtide, 76% patients said that they would be moderately or highly likely to accept a treatment offer, although most (72%) had not discussed enfuvirtide with their doctor. Patients' beliefs predicted the likelihood of accepting enfuvirtide.
              
              
                Conclusion
                Physician and patient beliefs about SIAT influence prescribing behavior and compliance yet may not be concordant, with patients having more positive attitudes towards SIAT than anticipated by physicians

TSpace (University of Toronto)

Horne, R

Kovacs, C

Katlama, C

Clotet, B

Fumaz, CR

Youle, M

Kulasegaram, R

Fisher, M

Cohen, C

Slim, J

Shalit, P

Cooper, V

Tsoukas, C

UCL Discovery

Prescribing and using self-injectable antiretrovirals: how concordant are physician and patient perspectives?

TSpace Repository

Robert  Horne

Colin Kovacs

Christine Katlama

Bonaventura Clotet

Carmina R Fumaz

Michael Youle

Ranjababu Kulasegaram

Martin Fisher

Calvin Cohen

Jihad Slim

Peter Shalit

Vanessa Cooper

Christos Tsoukas

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http://discovery.ucl.ac.uk/1351656/1/prescribing_pdf.pdf

Prescribing and using self-injectable antiretrovirals: How concordant are physician and patient perspectives?

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