The present investigation is an attempt to an ethnomedicinal plants survey was carried out in Sirumalai Hills, Dindigul district, Tamilnadu, for the exploration of various ailments herbal remedies. They routine use 40 medicinal plants for the treatment of several disease either in single or in combination with some other ingredients. The information on correct botanical identities with family, local name and traditional practice of 40 plant species belonging of 27 families are discussed here for the treatment of various illnesses