Binder, \u2704, Joseph B.

Roesner, Faculty Advisor, Rebecca A.

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Illinois Wesleyan UniversityDigital Commons @ IWUJohn Wesley Powell Student ResearchConference 2002, 13th Annual JWP ConferenceApr 21st, 9:00 AM - 10:00 AMDerivatization of Keggin-Type PolyoxometalatesJoseph B. Binder, '04Illinois Wesleyan UniversityRebecca A. Roesner, Faculty AdvisorIllinois Wesleyan UniversityFollow this and additional works at: http://digitalcommons.iwu.edu/jwprcThis Event is brought to you for free and open access by The Ames Library, the Andrew W. Mellon Center for Curricular and FacultyDevelopment, the Office of the Provost and the Office of the President. It has been accepted for inclusion in Digital Commons @ IWU bythe faculty at Illinois Wesleyan University. For more information, please contact digitalcommons@iwu.edu.©Copyright is owned by the author of this document.Joseph B. Binder, '04 and Rebecca A. Roesner, Faculty Advisor, "Derivatization of Keggin-Type Polyoxometalates" (April21, 2002). John Wesley Powell Student Research Conference. Paper 7.http://digitalcommons.iwu.edu/jwprc/2002/posters/7THE JOHN WESLEY POWELL STUDENT RESEARCH CONFERENCE.. APRIL 2002 Poster Presentation PI DERIV ATIZATION OF KEGGIN· TYPE POL YOXOMETALATES Joseph B. Binder and Rebecca A. Roesner* Department of Chemistry, Illinois Wesleyan University Polyoxometalates (POMs) of the Keggin structure, [XMl2040t-, are large metal-oxygen anions. They have shown significant antiviral activity, but failed in clinical trials due to their toxicity at the necessary dosages.l However, improving their bioselectivity through the attachment of appropriate ligands might decrease the required treatment levels and increase the POMs' therapeutic utility. We have worked to attach organic ligands to lacunary Keggin ions ([XMll039]n-), POMs in which a W -0 grollP is missing, leaving a hole into which another metal atom may be inserted. From [PWll039t, we have successfully synthesized [PWll039RhCH2COOHt, in which a rhodium atom bonded to a carboxylate group has entered the vacancy. Next, we modified the or§anic ligand by forming an amide bond to produce [PWll039RhCH2CONPh] -. Products have been characterized by lH and 3lp NMR. We plan to extend this chemistry to include other, more biologically relevant amines. lJ.T. Rhule, c.L. Hill, and D.A. Judd, "Polyoxometalates in Medicine," Chem. Rev. 1998, 98, 327-357. 

Derivatization of Keggin-Type Polyoxometalates

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Derivatization of Keggin-Type Polyoxometalates

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