Vyncke, Krishna

Ghent University Academic Bibliography

Arch Public Health 2010, 68 (Supplement 2), S86 1Ghent University, Department of Public Health, Ghent, Belgium  krishna.vyncke@ugent.be Interaction between diet and genetical predisposition on the fatty acid profile in healthy childrenand adolescents byVyncke K1Background Pathophysiological pathways leading to non-communicable diseases generally originate in early childhood and adolescence in function of lifestyle habits, genetical predisposition and early life programming of metabolic pathways. An important player in the pathophysiology of cardiovascular risk is the tissue availability of the omega-3 and omega-6 fatty acids of which the ratio is determined by extrinsic factors (i.e. nutrition and physical activity) and intrinsic factors (i.e. genetical predisposition). The combined influence of these determinants on se-rum lipids and fatty acid status in children and adolescents will be assessed.  MethodsAnthropometrics, dietary information and blood samples are available from a European co-hort of 3950 adolescents (aged 13-17 year) and 16000 children (aged 2-10 years). Similar data will be obtained in an obese population, recruited from the Paediatrics Obesity Clinic of Ghent University. A quantitative study of the influence of dietary habits on serum lipids and fatty acid status will be assessed using the Dietary Quality Index, an index developed to re-flect compliance with dietary guidelines. Consequently, the interaction between nutrition and relevant genes will be studied. Also a correlation between fatty acid status and early life fac-tors will be examined. Comparative studies will be performed between a subsample of the cohort of healthy children and adolescents and an age- and sex-matched, obese population.    ResultsThis abstract describes the core research of the author’s PhD project, which started in Octo-ber 2009 (promotors Prof. Dr S. De Henauw and Prof. Dr M. Van Winckel). First results are expected to be available by June 2011. Keywords Fatty acids, nutrition, genetics, child, adolescence 

Interaction between diet and genetical predisposition on the fatty acid profile in healthy children and adolescents

https://biblio.ugent.be/publication/1850644/file/1850652

Interaction between diet and genetical predisposition on the fatty acid profile in healthy children and adolescents

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