We present a new application for graph drawing and visualization in the context of drug discovery. Combining the scaffold-based cluster hierarchy with molecular similarity graphs — both standard concepts in cheminfor- matics — allows one to get new insights for analyzing large molecule libraries. The derived clustered graphs represent different aspects of structural similarity. We suggest visualizing them as topographic maps. Since the cluster hierarchy does not reflect the underlying graph structure as in (Gronemann and Jünger, 2012), we suggest a new partitioning algorithm that takes the edges of the graph into account. Experiments show that the new algorithm leads to significant improvements in terms of the edge lengths in the obtained drawings