Agnieszka Czarniecka

Daria Handkiewicz-Junak

Nowotwory Journal of Oncology

Directory of Open Access Journals

115Invited editorialNOWOTWORY Journal of Oncology 2021, volume 71, number 2, 115–116DOI: 10.5603/NJO.2021.0023© Polskie Towarzystwo OnkologiczneISSN 0029–540X, e-ISSN: 2300-2115www.nowotwory.edu.plWell-differentiated neuroendocrine neoplasms (NENs) of the digestive system – a diagnostic and therapeutic problem Daria Handkiewicz-Junak1, Agnieszka Czarniecka21Department of Nuclear Medicine and Endocrine Oncology, M. Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Poland2The Oncological and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, PolandHow to cite:Handkiewicz-Junak D, Czarniecka A. Well-differentiated neuroendocrine neoplasms (NENs) of the digestive system – a diagnostic and therapeutic problem. NOWOTWORY J Oncol 2021; 71: 115–116.The WHO classification system has emerged to distinguish between well-differentiated and poorly differentiated neuro-endocrine neoplasms (NENs) in order to prognostically stratify the neuroendocrine tumors (NETs) that are further classified according to the TNM classification [1].Typically, well-differentiated NETs are slow growing mali-gnancies, of which about 30–60% are metastatic at diagnosis and even approximately 30% of patients with completely resected localized disease develop metastases during follow--up [2]. Except for rare cases of radically resected liver metasta-ses, distant dissemination of NENs inevitably results in patient death. However, in some patients, death is related to heart failure in the course of carcinoid heart disease or a massive unresectable retroperitoneal desmoplastic reaction. Surgery is the only curable treatment for NENs. However, the expression of somatostatin receptors on the tumor cell surface makes NENs accessible for diagnostic and therapeu-tic approaches (theranostics) using radiolabeled peptides. The first somatostatin receptor imaging (SRI) was performed in 1989 with a gamma camera using somatostatin analogs radiolabeled with iodine 123 in a patient with a pancreatic neuroendocrine tumor. Since that time, SRI has developed and numerous studies have demonstrated the superior sensitivity of Ga-68-based PET/CT (around 90–100% in most NEN loca-lizations except for insulinoma). As a result, the current 2017 ENETS guidelines for radiological, nuclear medicine, and hybrid imaging [3] and follow-up of NET [4] guidelines consider SSA--PET/CT, if available, as the first-line diagnostic procedure for staging and NEN follow-up. A positive SRI scan means lesion uptake that is equal to or greater than the liver uptake and is a good predictor factor for effective biotherapy and radiola-beled therapy with somatostatin analogs [5,6]. In the present issue of Nowotwory. Journal of Oncology Tyrybon et al. presented a case of a patient with low-grade NEN of the small intestine who underwent surgery due to subileus. Although emergency surgery could suggest an ag-gressive disease, a retrospective study did not show that the signs of bowel obstruction before surgery were a prognostic factor of death in small-intestine NET (SI-NET) patients [1, 7]. However, emergency surgery is related to a lower number of resected lymph nodes and the risk of inappropriate staging [1]. This underlines the need for adequate postoperative staging using CT and SRI, which is in line with our opinion. Leaving the metastatic lymph node and a severe desmoplastic reaction may have resulted in relapse in this patient. When well-differentiated NETs recur with distant meta-stases, somatostatin analogs (SAs) are the first-line options in most patients except for fast growing tumors or with the risk of visceral crisis. For patients with oligometastatic disease, SA is the most reasonable treatment option, which results in disease stabilization of 12 months. Since SI-NETs have a poor response to chemotherapy, TOR inhibitors [8, 9] or radiolabeled This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.116somatostatin analogs are the second line of therapy [10]. mTOR inhibitors are not reimbursed in Poland. Therefore, radiolabeled somatostatin analogs (PRRT) are the only available option with an estimated median time of disease stabilization of about 3 years. High radiopeptide uptake in metastatic disease is the predictive factor for long-term response [6].Of note, during treatment, progression occurs in some lesions despite isotope accumulation. If it occurs in a vital organ, a patient must be carefully monitored and consulted in terms of the possibility of using other cytoreductive therapies. In the presented case, progression of recurrence in the heart may have resulted in the patient’s death. In oligometastatic disease without the symptoms of the carcinoid syndrome other causes are unlikely. AcknowledgmentsWe acknowledge the linguistic assistance provided by Assi-stant Professor Arkadiusz Badziński, PhD, a medical translator and interpreter.Conflict of interest: none declaredDaria Handkiewicz-JunakM. Sklodowska-Curie National Research Institute of Oncology Gliwice BranchDepartment of Nuclear Medicine and Endocrine Oncology  ul. Wybrzeże AK 15 44-101 Gliwice, Polande- mail: Daria.Handkiewicz-Junak@io.gliwice.plReceived and accepted: 2 Mar 2021References1. Baldys-Waligorska A, Nowak W. Neuroendocrine neoplasms of the digestive system-current classification and terminology. Nowotwory Journal of Oncology 2021; 71(1): 26-37, doi: 10.5603/NJO.2020.0020.2. Manguso N, Gangi A, Nissen N, et al. Long-Term Outcomes after Elective Emergency Surgery for Small Bowel Neuroendocrine Tumors. Am Surg. 2018; 84(10): 1570–1574, indexed in Pubmed: 30747671.3. Sundin A, Arnold R, Baudin E, et al. Antibes Consensus Conference par-ticipants. ENETS Consensus Guidelines for the Standards of Care in Neu-roendocrine Tumors: Radiological, Nuclear Medicine & Hybrid Imaging. Neuroendocrinology. 2017; 105(3): 212–244, doi: 10.1159/000471879, indexed in Pubmed: 28355596.4. Knigge U, Capdevila J, Bartsch DK, et al. Antibes Consensus Conference Participants, Antibes Consensus Conference participants. ENETS Con-sensus Recommendations for the Standards of Care in Neuroendocrine Neoplasms: Follow-Up and Documentation. Neuroendocrinology. 2017; 105(3): 310–319, doi: 10.1159/000458155, indexed in Pubmed: 28222443.5. Caplin ME, Pavel M, Ćwikła JB, et al. CLARINET Investigators. Lanreoti-de in metastatic enteropancreatic neuroendocrine tumors. N Engl J Med. 2014; 371(3): 224–233, doi: 10.1056/NEJMoa1316158, indexed in Pubmed: 25014687.6. Kwekkeboom DJ, de Herder WW, Kam BL, et al. Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survival. J Clin Oncol. 2008; 26(13): 2124–2130, doi: 10.1200/JCO.2007.15.2553, indexed in Pubmed: 18445841.7. Eriksson J, Garmo H, Hellman P, et al. The Influence of Preoperative Symptoms on the Death of Patients with Small Intestinal Neuroendo-crine Tumors. Ann Surg Oncol. 2017; 24(5): 1214–1220, doi: 10.1245/s10434-016-5703-4, indexed in Pubmed: 27904972.8. Yao JC, Fazio N, Singh S, et al. RAD001 in Advanced Neuroendocrine Tumours, Fourth Trial (RADIANT-4) Study Group. Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-con-trolled, phase 3 study. Lancet. 2016; 387(10022): 968–977, doi: 10.1016/S0140-6736(15)00817-X, indexed in Pubmed: 26703889.9. Chan DL, Segelov E, Singh S. Everolimus in the management of metastatic neuroendocrine tumours. Therap Adv Gastroenterol. 2017; 10(1): 132–141, doi: 10.1177/1756283X16674660, indexed in Pubmed: 28286565.10. Strosberg J, El-Haddad G, Wolin E, et al. NETTER-1 Trial Investigators. Phase 3 Trial of Lu-Dotatate for Midgut Neuroendocrine Tumors. N Engl J Med. 2017; 376(2): 125–135, doi: 10.1056/NEJMoa1607427, indexed in Pubmed: 28076709.

Well-differentiated neuroendocrine neoplasms (NENs) of the digestive system – a diagnostic and therapeutic problem

https://journals.viamedica.pl/nowotwory_journal_of_oncology/article/download/NJO.2021.0023/55517

Well-differentiated neuroendocrine neoplasms (NENs) of the digestive system – a diagnostic and therapeutic problem

Abstract

Similar works

Full text

Available Versions

Directory of Open Access Journals