On March 19th 2015 the Museum of Near East, Egypt and Mediterranean was officially opened by our Magnificus Rector Prof. Eugenio Gaudio in a completely renewed exhibit in the magnificent seat of the Crescent Hall of Marcello Piacentini within the Palace of the Rectorate of Sapienza University. Works of art and archaeological items collected by expeditions working all over the Near East and the Mediterranean were displayed illustrating interconnections and differences among several cultures enlightening the long and rich history of these regions. The article explains the concept which inspired the renewed exhibit and illustrates the main highlights of the Near Eastern, Egyptian and Mediterranean collections