Atopic dermatitis (AD) is a common, chronic, and relapsing inflammatory skin disorder characterized by skin irritation and intense pruritus, which significantly impairs the quality of patients’ life. Traditional Chinese medicine (TCM) has a long history in the treatment of atopic dermatitis, especially in preventing disease recurrence, minimizing adverse reactions and alleviating disease burden. In this paper, we reviewed the clinical anti-AD efficacy of Chinese herbal formulae from the perspective of AD mechanisms. Following assessment indicators were used: SCORing Atopic Dermatitis (SCORAD), erythema intensity, skin quality of life index (DLQI), pruritus intensity and frequency, transdermal dehydration (TEWL), and AD-mediated chemokine expression levels as index formulae. We also summarize the pharmacological effects of single herbs in the formulae. In conclusion, TCM has significant clinical efficacy for patients of all ages, both as a standalone treatment and in combination with other therapies
