Introduction: Bacterial infections affect an increasing portion of the population and pose a significant threat to global health. Treatment has become more challenging due to bacterial resistance to various antibiotics, leading to the need for alternative methods to combat these infections. One such method is vaccination prophylaxis.Aim: The aim of this study is to analyze data from scientific publications and assess the effectiveness of vaccines against some of the most common bacterial pathogens.Materials and Methods: This study was conducted using a literature review approach, focusing on articles published in PubMed and Google Scholar from 2019 to 2024.Results: Our study found that vaccination prophylaxis is a widely used method for combating various bacterial pathogens. A strict vaccination program and adherence to it significantly reduce the spread of life-threatening infectious diseases. In Bulgaria, immunization begins in maternity wards, while in some European countries, it starts after the second month of life.Conclusion: The increasing spread of bacterial infections can be mitigated by developing new vaccines and optimizing the prophylaxis of existing ones. Adherence to immunization schedules significantly reduces the spread of serious infections and improves public health
