Decarboxylative C–N Coupling of 2,2-Difluorobicyclo[1.1.1]pentane (BCP‑F₂) Building Blocks

Abstract

Described herein is our effort toward achieving the decarboxylative functionalization of 2,2-difluorobicyclo[1.1.1]­pentane (BCP-F2) building blocks. When compared with the nonfluorinated bicyclo[1.1.1]­pentane (BCP) analogues, we discovered divergent reactivities. This is the first successful decarboxylative coupling of BCP-F2 building blocks reported via the photoredox mechanism