Quantitative dissection of SANC pacemaking dysfunction in aging.

Abstract

(A-E) CO-MO parameter space maps at ZT6 and ZT18 under aged (A), aged MO (B), aged PNA (C), aged CO (D), and aged MO+PNA+CO (E) conditions. (F-H) Quantitative differences in flexibility (F), performance (G), and robustness (H) under various aging conditions. (I) Normalized changes in SANC flexibility, performance, and robustness compared to the control conditions in adult model.</p