The logarithm of expected number of mutated cells with the combination of different genetic mutations for the pathways involving <i>KRAS</i>⁺ → <i>APC</i>^+/− → <i>APC</i>^−/− → <i>TP</i>53^+/− → <i>TP</i>53^−/−, <i>APC</i>^+/− → <i>APC</i>^−/− → <i>TP</i>53^+/− → <i>TP</i>53^−/− → <i>KRAS</i>⁺ and <i>APC</i>^+/− → <i>APC</i>^−/− → <i>KRAS</i>⁺ → <i>TP</i>53^+/− → <i>TP</i>53^−/−.

Abstract

The values of parameters are decided by Tables 1–8.</p