Comparison of the histopathological changes after KA/E2 treatment in WT and TLR2 KO mice.

Abstract

Tissue inflammation was observed in the images of lung sections after H&E or PAS staining (A). Representative inflammation scoring and PAS-positive cells (mean ± SEM). A grade of 0 indicates no detectable inflammation and a grade 4 indicates high percentages of airways and blood vessels in section cuffing by inflammatory cells (0 = normal tissue; 1 = 75%). Severity scoring was based on the thickness of the bronchi or vessels surrounding inflammatory cells (0 = no cells; 1 = 1–3; 2 = 4–6; 3 = 7–9 cells thick; 4 = 10 or more cells thick). Means of the p-value were calculated for comparison to the control (n = 5 mice/group, 3 independent experiments, *; p < 0.05).</p