Additional file 1 of An area under the concentration–time curve threshold as a predictor of efficacy and nephrotoxicity for individualizing polymyxin B dosing in patients with carbapenem-resistant gram-negative bacteria

Abstract

Additional file 1: Figure S1. Scatterplot of polymyxin B AUCss,24h versus dosage. AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state. Figure S2. Scatterplot of polymyxin B AUCss,24h (a) and C0h (b) stratified for different stages of acute kidney injury. AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state; C0h, trough concentration. Figure S3. Kaplan-Meier estimates of survival to 30 days after administration of polymyxin B. Stratified by AUCss,24h (a) and C0h (b). AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state; C0h, trough concentration