A Cost-Effective Way to Produce Gram-Scale ¹⁸O‑Labeled Aromatic Aldehydes

Abstract

Obtaining 18O-labeled organic substances is of great research importance and also an extremely challenging work. In this work, depending on the reversed Knoevenagel reaction, 18O-labeled aromatic aldehydes (3a–3x) are successfully obtained with high total yields (52–72%) and sufficient 18O abundance (90.90–96.09%)