Additional file 1: Figure S1. The phylogenetic tree of MRP family members in D. melanogaster and the A. aegypti, related to Fig. 1. Figure S2. Localizations of Drosophila MRPs in S2 cell and their expressions under hemin supplementation in S2 or Aag2 cells. Figure S3. Phenotypic analysis of CG4562 and MRPs expression level in adults’ intestine, related to Fig. 5. Figure S4. Some residues of CG4562/dMRP5 could be mutated without influencing the transport activity, related to Fig. 6. Table S1. RNAi List of D. melanogaster. Table S2. qPCR Primers of D. melanogaster. Table S3. qPCR Primers of A. aegypti