Fibroblast mediated growth for <i>α</i> = 4 with clumped initial R-cell distribution.

Abstract

(A) The time evolution of the average of the total cell population () under CT-MTD in the 30 simulations is shown for all types of fibroblast configurations. (B) Boxplot of the TTP (time to progression) under CT-MTD in the 30 realizations. (C) Boxplot of the time gain under AT in the 30 realizations. (D) Correlation of TTP with the area of impact is shown. The circles and the asterisks (the colors are similar to the legend in A) show the TTP under CT-MTD and AT respectively. And the solid and dashed lines are the respective regression lines. The p − values for AT and CT-MTD indicate significance of the correlation. (E) Time gain (TG) is shown as boxplots for all type of fibroblast structures. (TIF)</p