Tetrahydroxydiboron and Nickel Chloride Cocatalyzed Rapid Radical Cyclization toward Pyrrolizidine and Indolizidine Alkaloids

Abstract

A novel tetrahydroxydiboron and nickel chloride cocatalyzed radical cyclization cascade with a broad substrate scope and an ultrashort reaction time was developed. The mechanistic investigation indicated that the reaction might involve a homocleavage of tetrahydroxydiboron and nickel hydride intermediates. This approach enables the simple and efficient synthesis of a series of heteropolycycles