Comparison of metabolites identified in the plasma of patients with cancer and healthy age-, sex-, and BMI-matched control participants. Fold-change analyses and unpaired t-tests were performed for each identified metabolite to identify differences in the relative abundance of individual metabolites between patients with cancer and control participants. p-values were false discovery rate (FDR)-adjusted to account for multiple comparisons Fold change (FC) analysis is defined as cancer/control, where a negative Log2(FC) indicates lower abundance in patients with cancer