Measurement and Correlation of Solubility and Thermodynamic Properties of Phenacetin in 12 Pure Solvents from 283.15 to 323.15 K

Abstract

In this research, the gravimetric method was utilized to measure the solubility of phenacetin from 283.15 to 323.15 K under atmospheric pressure in 12 solvents, including methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, ethyl formate, ethyl acetate, n-propyl acetate, N,N-dimethylacetamide, N,N-dimethylformamide, and acetonitrile. The solubility curves present an increasing trend with increasing temperature, and the mixing thermodynamic properties are also investigated in detail. Moreover, three thermodynamic models were used to correlate the experimental solubility data, and the fitting effect looks satisfactory as the average relative density is below 5%. The modified Apelblat model has the highest agreement with the experimental data compared with other models (λh model and NRTL model)