Additional file 3 of VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

Abstract

Additional file 3: Figure S2. Hypersensitivity-induced by VEGF-A family members is not due to the interaction with VEGFR-2. The response to a thermal stimulus (Cold plate test) was recorded after intrathecal infusion (30 ng) of (a) VEGF165b (n=5), (b) PlGF-2 (n=5), (c) VEGF-E (n=5), following pre-treatment (15 min before) with vehicle or anti-VEGFR-2 mAb DC101 (100 pg). Each value represents the mean ± SEM. **P<0.01 vs vehicle + vehicle-treated animals. The analysis of variance was performed by one-way ANOVA. A Bonferroni’s significant difference procedure was used as post-hoc comparison