Graph of pathway impact and relative <i>p</i>-value.

Abstract

Pathway analysis showing all matched pathways according to p-values from pathway enrichment analysis (y-axis) and pathway impact values from pathway topology analysis (x-axis). The colour and size of each circle are based on p-values and pathway impact values, respectively. Small p-values and large pathway impact circles indicate that the pathway is greatly perturbed. The top 5 pathways in order of p-values from the pathway analysis are numbered as follows: 1) pantothenate and CoA biosynthesis, 2) pyruvate metabolism, 3) glycolysis/ gluconeogenesis, 4) citrate cycle (TCA cycle) and 5) synthesis and degradation of ketone bodies.</p