Example of sensitivity analysis on a dataset which shows evidence for colocalisation at a predefined rule of posterior <i>P</i>(<i>H</i>4) > 0.5 only when the prior beliefs in H3 and H4 are approximately equal.

Abstract

The left hand panels show local Manhattan plots for the two traits, while the right hand panels show prior and posterior probabilities for H0-H4 as a function of p12. The dashed vertical line indicates the value of p12 used in initial analysis (the value about which sensitivity is to be checked). H0 is omitted from the prior plot to enable the relative difference for the other hypotheses to be seen.</p