Cross-Couplings of Unactivated Secondary Alkyl Halides:  Room-Temperature Nickel-Catalyzed Negishi Reactions of Alkyl Bromides and Iodides

Abstract

The development of a nickel- or palladium-catalyzed method for cross-coupling unactivated secondary alkyl halides has been a long-standing challenge in synthetic chemistry. This communication describes a simple catalyst system-Ni(cod)2/s-Bu-Pybox-that achieves room-temperature Negishi reactions of an array of functionalized primary and secondary alkyl bromides and iodides