<i>N</i>²-Phenyldeoxyguanosine:  Modulation of the Chemical Properties of Deoxyguanosine toward One-Electron Oxidation in DNA

Abstract

We have shown here that (1) substitution of an exocyclic amino group of dG is effective in modulating the chemical properties of dG toward one-electron oxidation and (2) decomposition of the guanine radical cation was effectively suppressed near dPhG. These results indicate that dPhG is a prototype of nucleosides functioning as an intrinsic antioxidant of duplex DNA toward one-electron oxidation