On the Introduction of a Trifluoromethyl Substituent in the Epothilone Setting:  Chemical Issues Related to Ring Forming Olefin Metathesis and Earliest Biological Findings

Abstract

The disclosure herein describes the synthesis of 10,11-dehydro-13,14-desoxy-27-trifluoro-[17]epothilone B via a stereoselective ring-closing metathesis and provides early biological evaluation data pertinent to this compound