Enantioselective Syntheses of Ring-C Precursors of Vit. B₁₂. Reagent Control

Abstract

Enelactones of the general structure S-(−)-I were prepared in three steps from alcohol 21 and acids 22 (ee ≈ 85%). Lactones S-(−)-I are versatile precursors to enelactams II of the type found in Vitamin B12