Total Synthesis of (−)-Aspidospermine via Diastereoselective Ring-Closing Olefin Metathesis

Abstract

An enantiocontrolled total synthesis of (−)-aspidospermine has been achieved. The key element of the strategy is the diastereoselective construction of the quaternary stereogenic center employing 1,4-asymmetric induction during the ring-closing olefin metathesis