Enantioselective Catalysis of Hetero Diels−Alder Reaction and Diethylzinc Addition Using a Single Catalyst

Abstract

Integration of two asymmetric reactions in one pot with the promotion of a single catalyst has been achieved in high efficiency and excellent stereoselectivity for hetero Diels−Alder reaction of Danishefsky's diene and diethylzinc addition to aldehydes. The strategy described in the present work demonstrated the ability of a single catalyst to promote two distinct enantioselective reactions in one pot