Proposed molecular mechanism for the function of p200 family proteins (IFI204) to inhibit IRF7-mediated activation of type I IFNs responses.

Abstract

Schematic diagram demonstrates the mechanism of p200 family proteins to suppress type I IFNs responses. Late after RNA virus infection, the highly expressed p200 family proteins, such as IFI204, interact with IRF7 in the nucleus and such interactions lead to the negative regulation of type I IFNs responses.</p