Feature importance study with input features perturbation method.

Abstract

The feature importance of AttnToCrispr_CNN on-target efficiency prediction model, which is trained with Crispr-Cas9 dataset in A) K562 cell line B) A549 cell line and C) NB4 cell line. Each dimer is two contiguous nucleotide bases on the input sequence. D) The feature importance of AttnToMismatch_CNN off-target specificity prediction model, which is trained with Crispr-Cas9 dataset. Each dimer is a nucleotide base pair, with one from a sgRNA and its counterpart in the target DNA.</p