<i>Trans</i>-eQTL colocalized in Alzheimer’s disease associated CLU locus.

Abstract

(A) The genotypes for Alzheimer’s disease susceptibility allele rs9331896 are significantly associated with the individual scores of component 22 (left panel). The component is active in monocytes (FF) in response to interferon-γ (right panel). (B). Circular plot demonstrating the chromosomal position of trans-eSNP (rs9331896) and the 38 trans target genes. The minor and AD-protective allele rs9331896-C is associated with decreased (blue lines) and increased (red lines) expression of trans-eGenes. The colored dots are trans-eQTL that replicates in ImmVar IFN stimulated monocytes (red and yellow color dots denote trans-eQTL association at FDR trans-eGenes with PIP > 0.5 and 2.5% distributional cut-off are shown. (C) IPA pathway analysis of the trans-eGenes in this component. The IPA canonical pathway enrichment P-values are shown in the lower right. The pathway network is grouped by IPA biological functions. The functional groups are defined by different colors and symbols (top right).</p