Additional file 1: of Low molecular weight heparin versus other anti-thrombotic agents for prevention of venous thromboembolic events after total hip or total knee replacement surgery: a systematic review and meta-analysis

Abstract

Figure S1. Sensitivity analysis using the leave-one-out approach of the influence of each study on the pooled estimate for comparing total VTE rate between LMWH vs. control (A) placebo, (B) inhibitor of factor Xa, and (C) direct thrombin inhibitor for THR and TKR patients. Abbreviations: CI, confidence interval; Lower limit, lower bound of the 95% CI; Upper limit, upper bound of the 95% CI. Figure S2. Sensitivity analysis using the leave-one-out approach of the influence of each study on the pooled estimate for comparing total DVT rate between LMWH vs. control (A) placebo, (B) inhibitor of factor Xa, and (C) direct thrombin inhibitor for THR and TKR patients. Abbreviations: CI, confidence interval; Lower limit, lower bound of the 95% CI; Upper limit, upper bound of the 95% CI. Figure S3. Sensitivity analysis using the leave-one-out approach of the influence of each study on the pooled estimate for comparing PE rate between LMWH vs. control (A) inhibitor of factor Xa, and (B) direct thrombin inhibitor for THR and TKR patients. Abbreviations: CI, confidence interval; Lower limit, lower bound of the 95% CI; Upper limit, upper bound of the 95% CI. Figure S4. Sensitivity analysis using the leave-one-out approach of the influence of each study on the pooled estimate for comparing major bleeding rate (A) inhibitor of factor Xa, and (B) direct thrombin inhibitor for THR and TKR patients. Abbreviations: CI, confidence interval; Lower limit, lower bound of the 95% CI; Upper limit, upper bound of the 95% CI. Figure S5. The results of quality assessment for (A) individual studies, and (B) the summary of bias for all included studies. Figure S6. Forest graph showing the incidence of major bleeding events. Figure S7. Forest graph showing reoperation rate in this population. Figure S8. Forest graph showing the immortality rate in this population. Figure S9. Forest graph showing the percentage of patients who discontinued treatment due to adverse reaction. Figure S10. Forest graph showing the incidence of cardiovascular events. Figure S11. Forest graph showing the incidence of stroke. Table S1. Summary of meta-analysis results. Table S2. Published systematic review and meta-analysis relating to thromboprophylasis after THR and TKR (DOCX 734 kb