(A-H) Sagittal sections of developing palate between midline and molar region showing in situ hybridization of Lrp4 (A, C, E, G) and Wise (B, D, F, H) in wild-type at E12.5 (A, B), E13.5 (C, D), E14.5 (E, F) and E16.5 (G, H). (C-H) Box showing large magnification images of developing rugae region. (I, J) Whole mount in situ hybridization of Lrp4 (I) and Wise (J) in wild-type palatal rugae at E14.5. Scale bar; 100μm (box in C-H), 200μm (A-D), 300μm (E, F), 400μm (G-J).</p