<i>Wise</i> expression during sequence of rugae appearance.

Abstract

(A-L) Oral views of palatal rugae showing expression of Shh (left palatal shelf) and Wise (right palatal shelf) in wild-type. Green and red arrowheads indicating region corresponding ruga 2 and 8, respectively. Left and right panel showing developing palatal shelf obtained from same embryo. Blue arrowheads indicating region corresponding newly formed ruga. Scale bar; 200μm (A-H), 400μm (I-L). (M) Oral views of palatal rugae showing expression of Shh (red) and Wise (blue) in wild-type. A-D; E11.5-E12.0, E, F; E12.0-E12.5, G, H; E12.5-E13.0, I, J; 13.0-E13.5, K, L, M; E13.5-E14.0. Images of Wise expression were horizontally flipped.</p