Pathway analysis of TCGA patients.

Abstract

(A) Canonical pathways in TCGA colon cancer patients as assessed by IPA. IL-6 and colorectal metastasis signaling were decreased. (B) GSEA showed that EMT and IL-6 signaling were reduced in the metformin-predicted group significantly. (C) mRNA expression of IL6, FN1, and MMP9 was decreased in the metformin-predicted group (TCGA dataset). *p p < 0.01, JAK: Janus kinase, ES: enrichment score, FDR: false discovery rate.</p