An unusually high substitution rate in transplant-associated BK polyomavirus <i>in vivo</i> is further concentrated in HLA-C-bound viral peptides - Fig 4

Abstract

Fraction of amino acid substitutions within and outside of predicted epitopes presented by HLA-A, -B and -C molecules across individuals. The detected amino acid substitutions of a viral population were mapped onto reference proteins and the fraction of mutated amino acids within and outside of predicted epitopes of each viral protein and hosts HLA allele were calculated for each viral population found in patient and donor respectively. The fraction of substituted amino acids within HLA-A and -B presented epitopes (yellow) is significantly lower compared with the fraction outside (blue), while the fraction of amino acid substitutions in HLA-C binding epitopes is significantly higher compared with the fraction outside.</p