Maximum likelihood (ML) tree based on an alignment of 510 heme oxygenase amino acid sequences from 1,678 taxa. Red algal heme oxygenases had three isotypes of heme oxygenase; HMOX1, HMOX2, and pbsA. HMOX1 and HMOX2 were located in the nuclear genome whereas the pbsA was encoded in the plastid genome in red algae.</p