Total Synthesis of (±)-Crinine via the Regioselective Stille Coupling and Diels−Alder Reaction of 3,5-Dibromo-2-pyrone

Abstract

The regioselective synthesis and Diels−Alder cycloaddition of 3-(3,4-methylenedioxyphenyl)-5-bromo-2-pyrone provided a new synthetic route to crinine. The vinyl bromide group can be used as a handle for further derivatization