Facile Synthesis and Functionality-Dependent Electrochemistry of Fe-Only Hydrogenase Mimics

Abstract

A series of azadithiolate (adt)-bridged Fe-only hydrogenase model complexes, Fe2(CO)6(μ-adt)C6H4I-4 (1), Fe2(CO)6(μ-adt)C6H4CCR [R = C6H4NO2-4 (2), C6H4CHO-4 (3), C6H4NH2-4 (4), C6H4COOH-4 (5), C6H4COOCH2CH3-4 (6), C6H4F-4 (7), C6H5 (8), C6H4OCH3-4 (9), C6H4N(CH3)2-4 (10)], [Fe2(CO)5(PPh3)(μ-adt)C6H4I-4 (11), and Fe2(CO)5(PPh3)(μ-adt)C6H4CCC6H4NO2-4 (12), have been synthesized in high yields under mild conditions. The linear geometry and rigidity of a triple bond act as an effective bridge to anchor a functionality ranging from electron-donating to electron-accepting, even coordinative groups in the adt model complexes. X-ray crystal analysis of 2, 3, and 6−12 reveals that the model complexes retain the butterfly structure of Fe2S2 model analogues. A rigid phenylacetylene offers excellent control over the distance between the functional group and the active site of Fe2S2 model complexes. The unusual Fe−Fe distance and the angles found in the molecular packing of 6 are originated from the intriguing intermolecular C−H···O and C−H···S interactions. More importantly, electrochemical studies reveal that all of the complexes can catalyze electrochemical reduction of protons to molecular hydrogen, but the reduction potential for the electron-transfer step can be remarkably altered by the functionality R. The electroreductively active nitro group in 2 and 12 displays the enhanced current at a potential substantially less negative than the reduction of [FeIFeI] + e− → [FeIFe0], which is most accessible and becomes the initial step. For complex 3, the second reduction peak for the electron-transfer step involves the contribution from the aldehyde functionality. As the electroreductively inactive groups are incorporated, the reduction process of [FeIFeI] + e− → [FeIFe0] appears first and the second reduction peak for the electron-transfer step from the [FeIFe0] + e− → [Fe0Fe0] process for 4−10 is clearly observed. Therefore, the order of electron and proton uptake is closely related to the electroreductively active functionality, R. Varying the nature of the functionality R leads to the electron-transfer step changes from the reduction of the electroreductively active R group to the active site of Fe2S2 model complexes subsequently. Accordingly, notwithstanding, acetic acid is too weak to protonate the series of 2−12, different reduction pathways can be followed, and the electrochemically catalyzed behavior may occur at different reduction levels