Intermolecular Decarboxylative Direct C-3 Arylation of Indoles with Benzoic Acids

Abstract

A palladium catalyzed C−H activation of indoles and a silver catalyzed decarboxylative C−C activation of ortho substituted benzoic acids are synergistically combined to synthesize indoles arylated exclusively in the C-3 position. This novel decarboxylative C−H arylation methodology is compatible with electron-donating and -withdrawing substituents in both coupling partners