Copper-Catalyzed Amidation of 2-Phenylpyridine with Oxygen as the Terminal Oxidant

Abstract

The Cu(OAc)2-catalyzed, O2-mediated amidation of 2-phenylpyridine via C−H bond activation is reported. A variety of nitrogen reagents including sulfonamides, carboxamides, and anilines participate in the reaction in moderate to good yields