Phenotype of CD4+ T-cells stimulated with the homologous DBLα-tag.

Abstract

<p>The phenotype of CD4+ T-cell in response to the homologous DBLα-tag was classified for each child and time point as followed: Th1, secretion of IFNγ alone or together with IL2 and/or IFNγ+IL10+; Th2, secretion of IL4 alone or in the presence of CD4+ T-cells secreting IL2 or IL10; IL2 alone: detection of only IL2-producing CD4+ T-cells; IL10 alone: detection of only IL10-producing CD4+ T-cells; mixed: detection of a mixed profile such as IFNγ-producing CD4+ T-cells together with IL4- or IL10-producing CD4+ T-cells or IL2- and IL10-producing CD4+ T-cells; none: children who did not induce any antigen-specific CD4+ T-cells. Shown are pie charts of the proportion of all children (A) with a particular profile or (B) grouped by disease severity.</p