<i>N. brasiliensis</i>-induced and IL-4Rα-mediated intestinal hypercontractility is impaired in iLck^creIL-4Rα^−/lox mice.

Abstract

<p>Jejunum pieces (1 cm) of non-infected and <i>N. brasiliensis</i> infected (PI day 7 and 10) mice were stimulated with KCl and contractility was measured (A). Comparison of the different mouse strains in response to acetylcholine is also shown for naïve, day 7 or day 10 infected IL-4Rα^−/lox, IL-4Rα^−/− and iLck^creIL-4Rα^−/lox mice (B). Contractility is shown as a mean value ± SEM for individual dose points. Graphs show three independent experiments with n = 12 in total. One-Way-ANOVA, *,# <i>P<.05</i>; **,## <i>P<.01</i>; ***,### <i>P<.001</i>. *indicates statistical significant differences between IL-4Rα^−/lox and IL-4Rα^−/−, # shows differences between IL-4Rα^−/lox and iLck^creIL-4Rα^−/lox mice.</p