Effect of 15-PGJ₂ treatment on LC3 and cathepsin-B immunoreactivity after cerebral I/R injury.

Abstract

<p>Double staining showed that LC3 punctate labeling and cathepsin-B immunoreactivity increased in neurons compared with sham-operated animals at 12 h after I/R injury. 15-PGJ2 at 50 pg effectively blocked the activation of autophagy as evidence by inhibiting immunoreactivity of LC3 (A) and cathepsin-B (B). Bar = 20 µm.</p